However, conflicting results have been described in an Egyptian case-control study that reported no significant difference in MPV value of psoriasis patients (n = 25) versus healthy controls (n = 25). Interestingly, MPV and RDW have been associated with the incident of primary adverse cardiac events in psoriasis vulgaris (PsV) and psoriatic arthritis (PsA), and linked to inflammatory status and clinical progression in psoriasis patients. As an example, the potential value of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) has been verified in the clinical diagnosis of ankylosing spongdylitis (AS), Behçet’s disease, rheumatoid arthritis (RA) and psoriasis.
To date, several studies have confirmed the role of some hematological parameters in certain diseases. The hematological parameters used most frequently are red blood cell (RBC), hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV), red cell distribution width (RDW), white blood cell (WBC), mean platelet volume (MPV), etc. Gaining more insight into the diagnostic information of hematological parameters is therefore considerable. However, examinations of these diagnostic biomarkers are time-consuming and costly compared with blood routine. Up to now, promising biomarker profiles of candidate gene expression (I元6G, CCL27, NOS2, C10orf99, and S100A9), plasma proteins (desmoplakin, cytokeratin 17, polymeric immunoglobulin receptor, and complement C3, PI3, CCL22, IL-12B), inflammatory cytokines (adiponectin), circulating microRNAs, GlycA have been reported to assist the clinical diagnosis and reflect disease severity and inflammation state of psoriasis. Given the limitation of invasiveness and hysteresis in existing diagnostic methods, diagnostic biomarkers can benefit patients greatly. The diagnosis of psoriasis primarily depends on three key items-the clinical characteristics of involving skin, nails and joints that are different from differential diagnosis frequency of disease development the skin biopsy. Psoriasis, a common chronic and systemic autoimmune inflammatory disease, is manifested with high individual heterogeneity symptoms, including recurrent scaly and burning skin patches, thick and dented nails, as well as swollen and stiff joints, complicated with a variety of other symptoms from cardiovascular, endocrine, digestive system and mental health. ZDYF2020147).Ĭompeting interests: The authors have declared that no competing interests exist. 2018CXTD350) and the Key R&D Projects in Hainan Province (No. 81560275), Hainan Province Clinical Medical Center, Innovation Research Team Project of Natural Science Foundation of Hainan Province (No. 2020JJ2055), National Natural Science Foundation of China (No. 2019RS2012), Hunan Outstanding Young Investigator (No. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This work was supported by the Hunan Talent Young Investigator (No. Received: MaAccepted: FebruPublished: February 25, 2022Ĭopyright: © 2022 Yi et al. PLoS ONE 17(2):Įditor: Muhammad Tarek Abdel Ghafar, Tanta University Faculty of Medicine, EGYPT (2022) Comparison of mean platelet volume (MPV) and red blood cell distribution width (RDW) between psoriasis patients and controls: A systematic review and meta-analysis. Citation: Yi P, Jiang J, Wang Z, Wang X, Zhao M, Wu H, et al.
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